| Business | Phone |
| De Soto First Baptist Church 301 N Hickory St, De Soto 62924 | (618) 867-2477 |
| De Soto United Methodist Chr 209 W Lincoln St, De Soto 62924 | (618) 867-2340 |
| Jubilee Tabernacle 503 Lewis St, De Soto 62924 | (618) 867-2924 |
| Mt Calvary Lutheran Church 114 S Oak St, De Soto 62924 | (618) 867-2418 |