| Business | Phone |
| United Methodist Church 302 S Illinois St, Karnak 62956 | (618) 634-2552 |
| St Catherine Catholic Church Grand Chain, Karnak 62956 | (618) 634-2206 |
| Living Hope Fellowship 344 State Highway 169, Karnak 62956 | (618) 634-2541 |
| Karnak Baptist Church 309 E Main, Karnak 62956 | (618) 634-2436 |