| Business | Phone |
| Manna Ministries Med Clinic 18 Stafford Rd, Picayune 39466 | (601) 749-7068 |
| Orthopedic Clinic 309 N Main St, Picayune 39466 | (601) 798-0535 |
| Pearl River Dialysis Unit 1835 Cooper Rd, Picayune 39466 | (601) 798-8951 |
| Picayune Rural Health Clinic 317 N Main St, Picayune 39466 | (601) 799-5577 |
| Womens Clinic 517 5th Ave, Picayune 39466 | (601) 798-1512 |