| Business | Phone |
| Alpha & Omega Child Care 1107 Clarke St, De Soto 63020 | (636) 337-5665 |
| Bright Beginning Learning Ctr 2195 Clarke St, De Soto 63020 | (636) 586-3664 |
| Tiny Town Child Care 13197 Timberwood Ln, De Soto 63020 | (636) 586-8836 |
| De Soto Daycare Ctr Inc 1733 Koch Ln, De Soto 63020 | (636) 586-1631 |
| De Soto Head Start 300 W Mineral St, De Soto 63020 | (636) 586-3453 |
| Jackie's Daycare 1017 Jennifer Dr, De Soto 63020 | (636) 337-3777 |