| Business | Phone |
| Agape Faith Church 3255 State Road V, De Soto 63020 | (636) 586-5148 |
| Apostolic Pentecostal Church 4521 State Route 110, De Soto 63020 | (636) 586-3032 |
| Beacon Baptist Church 300 E Clement St, De Soto 63020 | (636) 586-6353 |
| Calvary Baptist Church 12601 State Route 21, De Soto 63020 | (636) 586-4275 |
| St Andrew's United Methodist 1004 Rock Rd, De Soto 63020 | (636) 586-2472 |
| St Rose Of Lima School 504 S 3rd St, De Soto 63020 | (636) 337-2212 |
| Trinity Episcopal Church 202 W Miller St, De Soto 63020 | (636) 586-2542 |
| Valley View Church Of God 3818 Valles Mines Rd, De Soto 63020 | (636) 586-4466 |
| Victoria Baptist Church 3408 Bogey Ave, De Soto 63020 | (636) 586-2418 |
| De Soto Christian Church 4151 Fountain City Rd, De Soto 63020 | (636) 586-2061 |
| Desoto Faith Assembly 800 Amvets Dr, De Soto 63020 | (636) 586-1640 |
| Emmanuel Baptist Church 13270 State Road Cc, De Soto 63020 | (636) 586-6300 |
| First Assembly Of God-De Soto 12635 State Route 21, De Soto 63020 | (636) 586-2881 |
| First Baptist Church 400 Boyd St, De Soto 63020 | (636) 586-2500 |
| First Baptist Church Day Care 187 Phares Ln, De Soto 63020 | (636) 586-1500 |
| First Baptist Church Of Lucky 5305 State Road Y, De Soto 63020 | (636) 586-8354 |
| First Church Of God 300 W Mineral St, De Soto 63020 | (636) 586-3211 |
| First Freewill Baptist Church 1401 S 5th St, De Soto 63020 | (636) 586-6788 |
| First Pentecostal Church 3836 Fountain City Rd, De Soto 63020 | (636) 586-1449 |
| First United Methodist Church 200 Boyd St, De Soto 63020 | (636) 586-6431 |
| Mt Olive United Methodist Chr 13675 Mount Olive Rd, De Soto 63020 | (636) 586-0338 |
| Nazarene Desoto Church Po Box 97, De Soto 63020 | (636) 586-3597 |
| Oak Grove Baptist Church 7622 Old State Road H, De Soto 63020 | (573) 678-2222 |
| Oakland Baptist Church 6020 State Road H, De Soto 63020 | (636) 586-6512 |
| Park View Baptist Church 1531 Hillcrest Dr, De Soto 63020 | (636) 586-2243 |
| Rose Of Sharon Full Gospel 4311 Mcmillen Rd, De Soto 63020 | (636) 586-1800 |
| Grace Lutheran Church 121 W Kelley St, De Soto 63020 | (636) 586-2487 |
| Hope United Church Of Christ 113 S 3rd St, De Soto 63020 | (636) 586-6425 |
| Hopewell Assembly Of God Po Box 341, De Soto 63020 | (636) 586-8049 |
| Kingdom Hall-Jehovah's Witness 4423 State Route 110, De Soto 63020 | (636) 586-4833 |
| Landmark Missionary Baptist 1215 Boyd St, De Soto 63020 | (636) 586-3218 |
| Landmark Missionary Baptist 235 Tracy Ln, De Soto 63020 | (636) 337-0308 |