| Business | Phone |
| Comfort Inn 123 Huckleberry Heights Dr, Hannibal 63401 | (573) 221-9988 |
| Days Inn 4070 Market St, Hannibal 63401 | (573) 248-1700 |
| Econo Lodge 3604 Mcmasters Ave, Hannibal 63401 | (573) 221-0422 |
| Hannibal Inn 4141 Market St, Hannibal 63401 | (573) 221-6610 |
| Holiday Inn Express Hannibal 4000 Market St, Hannibal 63401 | (573) 406-0300 |
| Hotel Clemens 401 N 3rd St, Hannibal 63401 | (573) 248-1150 |
| Howard Johnson 3603 Mcmasters Ave, Hannibal 63401 | (573) 221-7950 |
| Mark Twain Hotel 202 S Main St, Hannibal 63401 | (573) 248-1273 |
| Quality Inn 8943 Highway 36, Hannibal 63401 | (573) 221-4001 |
| Super 7 612 Mark Twain Ave, Hannibal 63401 | (573) 221-1666 |
| Super 8 Motels 120 Huckleberry Heights Dr, Hannibal 63401 | (573) 221-5863 |
| Travelodge 500 Mark Twain Ave, Hannibal 63401 | (573) 221-4100 |