| Business | Phone |
| Bootheel Development Co-Op 6909 Us Highway 61, New Madrid 63869 | (573) 688-2004 |
| Daeoc County Office 420 Virginia Ave, New Madrid 63869 | (573) 748-5680 |
| Howardville Head Start 6916 Us Highway 61, New Madrid 63869 | (573) 688-2433 |
| New Madrid Family Resource Ctr 420 Virginia Ave, New Madrid 63869 | (573) 748-2778 |