| Business | Phone |
| Best Western 220 S Interstate Dr, Sikeston 63801 | (573) 471-9700 |
| Super 8 Motels 2609 E Malone Ave, Sikeston 63801 | (573) 471-7944 |
| Raudmont Inn 2608 E Malone Ave, Sikeston 63801 | (573) 471-4700 |
| Red Carpet Inn 110 S Interstate Dr, Sikeston 63801 | (573) 471-7400 |
| Midtowner Motel 833 E Malone Ave, Sikeston 63801 | (573) 471-5267 |
| Holiday Inn Express Sikeston 120 S Interstate Dr, Sikeston 63801 | (573) 481-9500 |
| Drury Inns 2602 E Malone Ave, Sikeston 63801 | (573) 471-4100 |
| Days Inn 1330 S Main St, Sikeston 63801 | (573) 471-3930 |
| Country Hearth Inn 100 Matthews Ln, Sikeston 63801 | (573) 472-4400 |