| Business | Phone |
| Best Western Inn 1808 W Lucas St, Florence 29501 | (843) 678-9292 |
| Budget Motel 2833 E Palmetto St, Florence 29506 | (843) 662-6375 |
| Colonial Inn 415 S Irby St, Florence 29501 | (843) 662-1486 |
| Comfort Inn 1916 W Lucas St, Florence 29501 | (843) 665-4558 |
| Country Inns & Suites Florence 1739 Mandeville Rd, Florence 29501 | (843) 317-6616 |
| Courtyard-Florence 2680 Hospitality Blvd, Florence 29501 | (843) 662-7066 |
| Days Inn 2123 W Lucas St, Florence 29501 | (843) 665-4444 |
| Days Inn 3783 W Palmetto St, Florence 29501 | (843) 665-8550 |
| Econo Lodge 1811 W Lucas St, Florence 29501 | (843) 665-8558 |
| Economy Inn 5235 E Palmetto St, Florence 29506 | (843) 662-2325 |
| Fairfield Inn 140 Dunbarton Dr, Florence 29501 | (843) 669-1666 |
| First Florence Corp 1914 W Lucas St, Florence 29501 | (843) 669-0855 |
| Florence Motel 414 S Irby St, Florence 29501 | (843) 662-1428 |
| Guesthouse International Inn 2001 W Lucas St, Florence 29501 | (843) 669-1921 |
| Hampton Inn 1826 W Lucas St, Florence 29501 | (843) 662-7000 |
| Hampton Inn 3000 W Radio Dr, Florence 29501 | (843) 629-9900 |
| Holiday Inn Express Florence 150 Dunbarton Dr, Florence 29501 | (843) 664-2400 |
| Holiday Inn Florence-I-95 1819 W Lucas St, Florence 29501 | (843) 665-4555 |
| Holiday Inn Hotel & Suites 2101 Florence Harllee Blvd, Florence 29506 | (843) 629-9774 |
| Magnolia Manor 2212 S Irby St, Florence 29505 | (843) 661-6801 |
| Microtel Inn & Suites 1912 Enterprise Dr, Florence 29501 | (843) 629-9522 |
| Motel 6 1834 W Lucas St, Florence 29501 | (843) 667-6100 |
| Park Inn 831 S Irby St, Florence 29501 | (843) 662-9421 |
| Red Roof Inn 2690 David H Mcleod Blvd, Florence 29501 | (843) 629-9784 |
| Rodeway Inn 3024 Tv Rd, Florence 29501 | (843) 669-1715 |
| Sleep Inn 1833 Florence Park Dr, Florence 29501 | (843) 662-8558 |
| Young's Plantation Inn 3111 Meadors Rd, Florence 29501 | (843) 669-4171 |
| Uptown Motel 311 S Irby St, Florence 29501 | (843) 662-0306 |
| Tree Top Inn 3932 W Palmetto St, Florence 29501 | (843) 662-7712 |
| Thunderbird Motel 2004 W Lucas St, Florence 29501 | (843) 669-1611 |
| Super 8 Motels 1832 1/2 W Lucas St, Florence 29501 | (843) 661-7267 |
| Swamp Fox Inn 3825 W Palmetto St, Florence 29501 | (843) 665-0803 |
| Swamp Fox Inn Ih 95 & Us 76amp;, Florence 29501 | (843) 665-0803 |
| Star Motel 2917 E Palmetto St, Florence 29506 | (843) 669-6472 |
| Springhill Suites By Marriott 2670 Hospitality Blvd, Florence 29501 | (843) 317-9050 |