| Business | Phone |
| Best Western Inn I95 Exit 98 E, Santee 29142 | (803) 854-3089 |
| Clark's Inn 114 Bradford Blvd, Santee 29142 | (803) 854-2141 |
| Comfort Inn 249 Britain St, Santee 29142 | (803) 854-3221 |
| Country Inn & Suites 221 Britain St, Santee 29142 | (803) 854-4104 |
| Days Inn 9078 Old Number Six Hwy, Santee 29142 | (803) 854-2175 |
| Delta Motel 1825 Bass Dr, Santee 29142 | (803) 854-5900 |
| Hampton Inn 9060 Old Number Six Hwy, Santee 29142 | (803) 854-2444 |
| Holiday Inn 139 Bradford Blvd, Santee 29142 | (803) 854-9800 |
| Holiday Inn Santee 8929 Bass Dr, Santee 29142 | (803) 854-2121 |
| Howard Johnson 9112 Old Number Six Hwy, Santee 29142 | (803) 854-3870 |
| Mansion Park Motor Lodge 656 Bass Dr, Santee 29142 | (803) 854-2334 |
| Ramada Inn 123 Mall St, Santee 29142 | (803) 854-2191 |
| Santee Economy Inn 628 Bass Dr, Santee 29142 | (803) 854-2107 |
| Santee Management Inc Village Square Blvd 4 # E3, Santee 29142 | (803) 854-2222 |
| Super 8 Motels 9125 Old Number Six Hwy, Santee 29142 | (803) 854-3456 |
| Swamp Fox Motel 326 Bass Dr, Santee 29142 | (803) 854-3378 |
| Travelodge Hotels 9091 Old Number Six Hwy, Santee 29142 | (803) 854-3122 |