| Business | Phone |
| City Of Seneca 621 N Townville St, Seneca 29678 | (864) 885-1024 |
| Seneca Building Inspector 221 E North 1st St, Seneca 29678 | (864) 885-2737 |
| Seneca City Administrator 221 E North 1st St, Seneca 29678 | (864) 885-2721 |
| Seneca Clerk 221 E North 1st St, Seneca 29678 | (864) 885-2700 |
| Seneca Engineering 251 E North 2nd St # 207, Seneca 29678 | (864) 885-2724 |
| Seneca Light & Water Plant 221 E North 1st St, Seneca 29678 | (864) 885-2723 |
| Seneca Water Filter Plant 630 Northampton Rd, Seneca 29672 | (864) 885-2735 |