| Business | Phone |
| First Assembly Of God 901 S Highway 181, Karnes City 78118 | (830) 780-2891 |
| First Baptist Church 406 E Calvert Ave, Karnes City 78118 | (830) 780-3147 |
| First Presbyterian Church 405 E Mayfield St, Karnes City 78118 | (830) 780-3538 |
| First United Methodist Church 201 N Esplanade St, Karnes City 78118 | (830) 780-3307 |
| St Paul Lutheran Church 408 S Davidson St, Karnes City 78118 | (830) 780-2251 |
| Calvary Baptist Mission 301 E Milam St, Karnes City 78118 | (830) 780-3124 |
| St Boniface Catholic Church Po Box 135, Karnes City 78118 | (830) 780-3559 |
| St Cornelius Catholic Church 605 E Calvert Ave, Karnes City 78118 | (830) 780-3947 |
| Prospect Baptist Church 303 W Buchel Ave, Karnes City 78118 | (830) 780-4245 |
| Pastor Catholic 605 E Calvert Ave, Karnes City 78118 | (830) 780-8882 |