| Business | Phone |
| Karnes City Independent School 221 N Esplanade St, Karnes City 78118 | (830) 780-2048 |
| Karnes City Independent School 314 E Highway 123, Karnes City 78118 | (830) 780-2688 |
| Karnes City Independent School 319 E Mayfield St, Karnes City 78118 | (830) 780-2731 |
| North Elementary School 405 N Browne St, Karnes City 78118 | (830) 780-2243 |
| Karnes City Superintendent's 400 E Highway 123, Karnes City 78118 | (830) 780-2321 |