| Business | Phone |
| Family Care Pharmacy 1627 E Us Highway 83, Rio Grande City 78582 | (956) 488-1660 |
| Fred's Pharmacy 2790 Pharmacy Rd, Rio Grande City 78582 | (956) 487-2711 |
| H-E-B Pharmacy 6583 Bridge Rd, Rio Grande City 78582 | (956) 487-4635 |
| Oscar's Pharmacy 5322 E Us Highway 83 C1, Rio Grande City 78582 | (956) 488-8700 |