| Business | Phone |
| National Car Rental 1411 Coulter Dr Nw, Roanoke 24012 | (540) 366-6210 |
| Avis Rent A Car 1304 Municipal Rd Nw, Roanoke 24012 | (540) 366-9406 |
| Avis Rent A Car 3137 Brambleton Ave, Roanoke 24018 | (540) 989-3700 |
| Avis Rent A Car 1306 Municipal Rd Nw, Roanoke 24012 | (540) 366-2436 |
| Budget Rent A Car 4202 Brambleton Ave, Roanoke 24018 | (540) 400-7998 |
| Enterprise Rent-A-Car 1603 Williamson Rd Ne, Roanoke 24012 | (540) 343-8000 |
| Enterprise Rent-A-Car 2820 Electric Rd, Roanoke 24018 | (540) 776-3128 |
| Enterprise Rent-A-Car 3507 Franklin Rd Sw, Roanoke 24014 | (540) 985-4852 |
| Enterprise Rent-A-Car 5202 Aviation Dr Nw, Roanoke 24012 | (540) 563-8055 |
| Enterprise Rent-A-Car 5537 Airport Rd, Roanoke 24012 | (540) 366-9004 |
| Four Star Rent A Car 4345 Old Cave Spring Rd, Roanoke 24018 | (540) 774-1750 |
| Hertz Rent A Car 5202 Aviation Dr Nw, Roanoke 24012 | (540) 366-3421 |
| Alamo Car Rental 5202 Aviation Dr Nw, Roanoke 24012 | (540) 563-5050 |