| Business | Phone |
| Abingdon Presbytery 890 W Spiller St, Wytheville 24382 | (276) 228-5588 |
| Baker's Chapel Ph Church Rr 3, Wytheville 24382 | (276) 699-2265 |
| Bethlehem Baptist Church 1300 W Monroe St, Wytheville 24382 | (276) 223-1795 |
| Church Of Christ 1525 W Pine St, Wytheville 24382 | (276) 228-6448 |
| Cripple Creek United Methodist 1131 Slate Spring Branch Rd, Wytheville 24382 | (276) 621-4832 |
| Crossroads Church Of Christ 1390 W Lee Hwy, Wytheville 24382 | (276) 228-7800 |
| Dayspring Fellowship Church 760 E Main St, Wytheville 24382 | (276) 228-4306 |
| Granite Christian Academy 1705 Peppers Ferry Rd, Wytheville 24382 | (276) 228-3129 |
| First Christian Church 140 S 10th St, Wytheville 24382 | (276) 223-1566 |
| First Christian Church 640 W Main St, Wytheville 24382 | (276) 223-1566 |
| Franklin Street United Mthdst 430 E Franklin St, Wytheville 24382 | (276) 228-7095 |
| Holy Trinity Lutheran Church 405 W Main St, Wytheville 24382 | (276) 228-2171 |
| Kingdom Hall-Jehovah's Witness 250 Grayson Rd, Wytheville 24382 | (276) 228-7452 |
| Lebanon Lutheran Church 174 Carterville Heights Rd, Wytheville 24382 | (276) 637-6258 |
| Liberty Hill Pentecostal Chr 100 Old School Rd, Wytheville 24382 | (276) 699-1925 |
| Light Of Hope Church 856 New Bethel Rd, Wytheville 24382 | (276) 686-2215 |
| Morning Star Church Of God 400 E Franklin St, Wytheville 24382 | (276) 228-5388 |
| Mt Calvary Apostolic Church 290 E Liberty St, Wytheville 24382 | (276) 223-0082 |
| Mt Pleasant United Methodist 200 Mount Pleasant Rd, Wytheville 24382 | (276) 223-1492 |
| New Covenant Fellowship Church 2150 W Ridge Rd, Wytheville 24382 | (276) 228-7351 |
| Open Door Baptist Church Highway 11, Wytheville 24382 | (276) 686-5555 |
| Original Church Of God 220 S 11th St, Wytheville 24382 | (276) 228-6260 |
| Word Of Life Ministries 2010 W Ridge Rd, Wytheville 24382 | (276) 223-1972 |
| Wytheville Baptist Church 205 Church St, Wytheville 24382 | (276) 228-3712 |
| Wytheville First Church Of God 1135 Cove Rd, Wytheville 24382 | (276) 223-1704 |
| Wytheville Methodist Circuit 4922 W Lee Hwy, Wytheville 24382 | (276) 686-4422 |
| Wytheville Presbyterian Church 285 Church St, Wytheville 24382 | (276) 228-4715 |
| Wilderness Road Ph 375 N 24th St, Wytheville 24382 | (276) 223-1557 |
| Walker Mountain Luth Parish 3570 W Lee Hwy, Wytheville 24382 | (276) 228-6322 |
| Petunia Christian Church 2420 W Lee Hwy, Wytheville 24382 | (276) 228-4953 |
| United Methodist Church 105 Asbury Ln, Wytheville 24382 | (276) 228-4922 |
| Providence Reformed Presbyter 180 W Main St, Wytheville 24382 | (276) 625-0880 |
| Transport For Christ 1025 Peppers Ferry Rd, Wytheville 24382 | (276) 223-1683 |
| Truth & Praise Tabernacle Chr 800 E Lexington St, Wytheville 24382 | (276) 228-7707 |
| Rosenbaum Chapel Ph Church 1469 Cripple Creek Rd, Wytheville 24382 | (276) 621-5200 |
| Sunny Hills Community Church 630 W Franklin St, Wytheville 24382 | (276) 228-7599 |
| Seventh Day Adventist Church 1600 Chapman Rd, Wytheville 24382 | (276) 228-4301 |
| St John's Episcopal Church 275 E Main St, Wytheville 24382 | (276) 228-2562 |
| St Mary Mother-God Catholic 370 E Main St, Wytheville 24382 | (276) 228-3104 |
| St Paul United Methodist Chr 330 Church St, Wytheville 24382 | (276) 228-5539 |