| Business | Phone |
| Cooperative Extension Office 275 S 4th St, Wytheville 24382 | (276) 223-6040 |
| County Commissioner Of Revenue 225 S 4th St 203, Wytheville 24382 | (276) 223-6015 |
| County Magistrate's Ofc 245 S 4th St, Wytheville 24382 | (276) 223-6090 |
| County Treasurer's Ofc 225 S 4th St 104, Wytheville 24382 | (276) 223-6070 |
| County Voter Registration 245 S 4th St 101, Wytheville 24382 | (276) 223-6038 |
| Fuel Assistance Program 275 S 4th St, Wytheville 24382 | (276) 228-5604 |
| Juvenile Domestic Relations 225 S 4th St 204, Wytheville 24382 | (276) 223-6080 |
| Wythe County It Dept 1505 W Reservoir St, Wytheville 24382 | (276) 228-6829 |
| Wythe County Trash Collection 6449 Grayson Tpke, Wytheville 24382 | (276) 621-5251 |
| Wythe County Trash Collection 793 Slate Spring Branch Rd, Wytheville 24382 | (276) 621-4501 |
| Wythe County Trash Collection N 4th St, Wytheville 24382 | (276) 920-7748 |
| Wytheville Dog Pound 600 Atkins Mill Rd, Wytheville 24382 | (276) 228-6003 |
| Special Federal Projects 1570 W Reservoir St, Wytheville 24382 | (276) 228-9192 |