| Business | Phone |
| Best Western Inn 355 Nye Rd, Wytheville 24382 | (276) 228-7300 |
| Budget Host Inn 705 Chapman Rd, Wytheville 24382 | (276) 228-8618 |
| Comfort Inn 2594 E Lee Hwy, Wytheville 24382 | (276) 637-4281 |
| Comfort Inn 315 Holston Rd, Wytheville 24382 | (276) 228-4488 |
| Days Inn 150 Malin Dr, Wytheville 24382 | (276) 228-5500 |
| Econo Lodge 1160 E Main St, Wytheville 24382 | (276) 228-5517 |
| Hampton Inn 950 Peppers Ferry Rd, Wytheville 24382 | (276) 228-6090 |
| Holiday Inn 1800 E Main St, Wytheville 24382 | (276) 228-5483 |
| Motel 6 220 Lithia Rd, Wytheville 24382 | (276) 228-7988 |
| Quality Inn 2015 E Main St, Wytheville 24382 | (276) 228-4241 |
| Travel Lite Motel 655 E Main St, Wytheville 24382 | (276) 228-5574 |
| Travelodge 140 Lithia Rd, Wytheville 24382 | (276) 228-3188 |
| Ramada Inn 955 Peppers Ferry Rd, Wytheville 24382 | (276) 228-6000 |
| Red Carpet Inn 280 Lithia Rd, Wytheville 24382 | (276) 228-5525 |
| Riddhi Vinayak Inc 355 Nye Rd, Wytheville 24382 | (276) 228-6582 |
| Super Motel 130 Nye Cir, Wytheville 24382 | (276) 228-6620 |
| Sleep Inn 135 Nye Cir, Wytheville 24382 | (276) 625-0667 |